Role of prm-binding protein domains
Only a minor fraction of the proteome is considered as druggable
Addressable using Conventional Drugs
Proteins containing PRM-binding domains
Proline-rich motif (PRM) mediated interactions are the most frequent type of protein-protein interaction in our organism.
The challenge to unlock this undruggable class of targets lies in the unique helical structure they are specialized in recognizing. Until now, all attempts to mimic this specific shape with small molecules have failed.
That is exactly where our technology comes into play.
We combine our ProMs with our Development Platform to build a diversified pipeline of high value assets.
Based on our modular synthetic approach we are able to fast-track the generation of ProM-based low molecular weight inhibitors for a target of choice
We enable an accelerated lead-to-candidate phase based on computational modeling simulations and rapid compound synthesis
Manufacturing relies on established and reproducible synthetic procedures, allowing reliable and fast upscaling
Structurally novel drug
Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells