Our Science
Unlocking an entirely new space within the proteome based on our proprietary platform


Role of prm-binding protein domains
Proteome
Only a minor fraction of the proteome is considered as druggable
10 %
Addressable using Conventional Drugs10 %
Proteins containing PRM-binding domains
Proline-rich motif (PRM) mediated interactions are the most frequent type of protein-protein interaction in our organism.
They are fundamental drivers of cellular malfunctions resulting in e.g. cancer cell migration, fibrosis as well as in bacterial and viral pathogenesis.
Selected Targets
The challenge to unlock this undruggable class of targets lies in the unique helical structure they are specialized in recognizing. Until now, all attempts to mimic this specific shape with small molecules have failed.
That is exactly where our technology comes into play.
PLATFORM
We combine our ProMs with our Development Platform to build a diversified pipeline of high value assets.
Step 1:
Generating
Based on our modular synthetic approach we are able to fast-track the generation of ProM-based low molecular weight inhibitors for a target of choice
Step 2:
Optimizing
We enable an accelerated lead-to-candidate phase based on computational modeling simulations and rapid compound synthesis
Step 3:
Upscaling
Manufacturing relies on established and reproducible synthetic procedures, allowing reliable and fast upscaling
Structurally novel drug
Pipeline
Development Pipeline
Discovery
Preclinical Validation
Lead Optimization
Ind-enabling
Phase I
Phase II/III
PST010
Oncology
PST020
Infectious Diseases
PST030
Oncology
PST040
CNS